quipazine

Quipazine 是一种5-HT 激动剂，取代大鼠内皮层中 5-HT3R 的 [3H]GR65630 的Ki 值为 1.4 nM。Quipazine 对SARS-CoV-2具有抗病毒活性，EC50值为 31.64 μM。Quipazine 在外周模型中表现为 5-HT3R 的激动剂，可用于神经疾病研究。

Quipazine dimaleate 是一种选择性 5-HT3 激动剂。

Quipazine maleate is a selective 5-HT receptor agonist that promotes the proliferation and apoptosis of human hepatocyte strain of L-02 strain and could also exert an excitatory effect on raphe neurons via stimulation of 5-HT2A receptors. Like quipazine, quipazine derivatives produce contracture of smooth muscle organs and bronchospasm.

N-Methylquipazine is an agonist of 5-HT3. It has almost the same affinity for 5-HT3 sites as quipazine.

5-HT3 agonist

Seganserin 是一种非选择性5-羟色胺2-HT 受体拮抗剂，可逆转了氟西汀和喹帕嗪对黄体酮诱导的食欲亢进，抑郁和痛觉的抑制作用，逆转氟西汀和喹帕嗪诱导的抗抑郁和镇痛作用。