psam

PSEM 89S TFA 是一种脑渗透性和选择性离子通道激动剂，分别对 Q79G 和 L141F 具有正交选择性。

Lycopsamine N-oxide 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T123864。

7-O-Acetyllycopsamine N-oxide 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124402。

Psammaplysene A is a FOXO1a nuclear export inhibitor.

Psammaplysene B is a FOXO1a nuclear export inhibitor.

Lycopsamine is a bioactive chemical.

Lycopsamine `1-acetate is a bioactive chemical.

Psammaplin A, a marine metabolite, functions as a robust inhibitor of HDAC and DNA methyltransferases, displaying notable potency and selectivity as a DAC1 inhibitor, with an IC50 value of 0.9 nM. It exhibits antimicrobial effects against Gram-positive bacteria and inhibits both DNA synthesis and DNA gyrase activity, also demonstrating antitumor activity[1][2].

Sp-cAMPS-AM, 作为cAMP的一个类似物，主要通过渗透细胞并释放其母体极性结构Sp-cAMPS来发挥功能，进而诱导PKA激活和CREB磷酸化。

PSAM (pharmacologically selective actuator module) agonist. Activates PSAML141F-GlyR chimeric ion channels. Inhibits activity of neurons expressing PSAML141F-GlyR in vivo and activates locus coeruleus noradrenergic neurons expressing PSAML141F,Y115F-5-HT3 ion channels. Recommended concentration for use in mice is 5 mg kg or lower. Plasmid vectors for the transfection of cells with PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 are available from Addgene. Lovett-Barron et al (2012) Regulation of neuronal input transformations by tunable dendritic inhibition. Nat.Neurosci. 15 423 PMID:22246433 |Satoh et al (2016) Context-dependent gait choice elicited by EphA4 mutation in Lbx1 spinal interneurons. Neuron 89 1046 PMID:26924434 |Atasoy et al (2012) Deconstruction of a neural circuit for hunger. Nature 488 172 PMID:22801496 |Hirschberg et al (2017) Functional dichotomy in spinal- vs prefrontal-projecting locus coeruleus modules splits descending noradrenergic analgesia from ascending aversion and anxiety in rats. Elife 6 e29808 PMID:29027903