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TargetMol产品目录中 "

probucol

"的结果
  • 抑制剂&激动剂
    8
    TargetMol | Inhibitors_Agonists
  • 天然产物
    2
    TargetMol | Natural_Products
  • Probucol
    普罗布考, DH-581
    T025423288-49-5
    Probucol (DH-581) 是一种抗高脂血症药物,可通过增加 LDL 分解代谢率来降低血液中的胆固醇水平。
    • ¥ 158
    In stock
    规格
    数量
  • Succinobucol
    Probucol monosuccinate, AGI-1067
    T4287216167-82-7
    Succinobucol (Probucol monosuccinate) 是酚类抗氧化剂,具有抗炎、抗血小板聚集活性。
    • ¥ 129
    In stock
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  • Probucol dithiobisphenol
    Probucol dithiobisphenol, DTBP
    T2052166386-58-9
    Probucoldithiobisphenol (DTBP) 是 Probucol 的一种衍生物。Probucol dithiobisphenol 通过诱导血红素加氧酶 1 (HO-1) 的生成展示出其抗氧化特性。在 Apoe− − 小鼠中,Probucol dithiobisphenol 可有效抑制主动脉的动脉粥样硬化病变,并在兔的动脉损伤模型中促进动脉内皮的再生和抑制再狭窄。此外,Probucol dithiobisphenol 拥有良好的口服活性。
    • 待询
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  • Probucol disuccinate
    T4179216168-45-5
    Probucol disucinate 是一种 Probucol 的衍生物。其中 Probucol 是脂质调节的化合物,它能降低 LDL-cholesterol 水平。
    • ¥ 162
    In stock
    规格
    数量
  • RC363
    T365152584411-86-7
    RC363 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1It reduces 2,2-diphenyl-1-picrylhydrazyl radicals by approximately 40% in a cell-free assay when used at a concentration of 25 μM. RC363 prevents glutamate-induced toxicity in HT22 cultured hippocampal cells (IC50= 234.5 nM) but does not reduce oxidant levels in these cells. It increases the levels of glutathione peroxidase 1 (GPX1) and the activity of GPX in glutamate-challenged HT22 cells when used at a concentration of 3 μM. RC363 inhibits ferroptosis induced by the GPX4 inhibitor RSL3 in HT22 cells (IC50= 173.6 nM). 1.Bueno, D.C., Canto, R.F.S., de Souza, V., et al.New probucol analogues inhibit ferroptosis, improve mitochondrial parameters, and induce glutathione peroxidase in HT22 cellsMol. Neurobiol.57(8)3273-3290(2020)
    • ¥ 443
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  • RC574
    RC574
    T36516584411-87-8
    RC574 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1It inhibits glutamate-induced cell death in HT22 cells (IC50= 276.2 nM) and mouse primary cortical neurons when used at a concentration of 3 μM. RC574 (3 μM) increases glutathione peroxidase 1 (GPX1) levels and GPX activity, as well as inhibits glutamate-induced mitochondrial superoxide anion production, in HT22 cells. It completely inhibits ferroptosis induced by the GPX4 inhibitor RSL3 in HT22 cells when used at concentrations ranging from 62.5 to 1,000 nM. 1.Bueno, D.C., Canto, R.F.S., de Souza, V., et al.New probucol analogues inhibit ferroptosis, improve mitochondrial parameters, and induce glutathione peroxidase in HT22 cellsMol. Neurobiol.57(8)3273-3290(2020)
    • ¥ 579
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  • Tiliroside
    银椴苷;椴树苷, 银椴甙, Tribuloside
    T5S117220316-62-5
    Tiliroside (Tribuloside) 是糖苷类黄酮,是 α-淀粉酶的非竞争性抑制剂(Ki:84.2 μM)。它抑制胃肠道中碳水化合物的消化和葡萄糖的吸收,具有抗糖尿病作用。
    • ¥ 233
    In stock
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    数量
  • Isosalvianolic acid C
    异丹酚酸C
    TN1801142115-17-1
    Isosalvianolic acid C exhibits more potent activity than probucol except for salvianolic acid F .
    • ¥ 10360
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