porcine rbc

Globotetraosylceramides are bioactive neutral glycosphingolipids. They are the major glycolipids in human erythrocytes. They act as receptors for the Shiga toxins Stx1, Stx2, and Stx2e, the cytotoxic protein pierisin-1, and parvovirus B19. Globotetraosylceramides increase the expression of proteins responsible for enamel deposition, including ameloblastin, amelogenin, and enamelin, in dental epithelial cells and activate the ERK and p38 MAPK signaling pathways. Levels of globotetraosylceramides are elevated in fibroblasts from patients with salt and pepper syndrome, a neurocutaneous condition characterized by intellectual disability and hyper- and hypo-pigmented skin. Globotetraosylceramides (porcine RBC) contains a mixture of globotetraosylceramides with variable fatty acyl chain lengths isolated from porcine red blood cells.

Globotriaosylceramide (non-hydroxy) (porcine RBC) 是一种糖鞘脂，存在于哺乳动物细胞膜中，是法布里病的主要致病分子，其水平可通过补充 α-半乳糖苷酶 A 下调。该化合物通过调控共受体CD19的定位来增强 B 细胞受体信号，可作为疫苗佐剂，引导产生广谱且具交叉保护的抗体应答。此外，Globotriaosylceramide (non-hydroxy) (porcine RBC) 还能通过调节成纤维细胞的异质性促进伤口愈合，并减少瘢痕形成。

Lactosylceramide (LacCer) (porcine RBC) 是一种内源性生物活性鞘脂，在介导先天免疫功能方面具有重要作用。