plosl 2

TREM-2 (Triggering Receptor Expressed on Myeloid cells-2) is a 35 kDa type I transmembrane member of the TREM family and Ig superfamily. Mature human TREM-2  consists of a 156 amino acid (aa) extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane (TM) domain, and a 35 aa cytoplasmic tail. TREM-2 forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849). Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia.

Expression system: HEK293 Cells
Length: 19-174, Extracellular Domain
Activity: Not Tested

Expression system: HEK293 Cells
Length: 19-174, Extracellular Domain
Activity: Not Tested

TREM-2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 20.69 kDa and the accession number is NP_061838.1.

Expression system: HEK293 Cells
Length: 1-168, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-174, Extracellular Domain
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-168, Partial
Activity: Not Tested

TREM-2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.16 kDa and the accession number is NP_061838.1.