pi-14

GPI-1485 (GM1485) 是一种免疫抑制的特异性亲免蛋白配体，可促进中风后的神经功能改善和神经再生。

FPI-1465 是丝氨酸-β-内酰胺酶和青霉素结合蛋白 (PBP) 的双重抑制剂。FPI-1465 抑制PBP2，IC50为 1.0 μg mL。FPI-1465 作用于 β-内酰胺酶 CTX-M-15 和 OXA-48，Kd 分别为 0.011 和 5.3 μM。

Duvelisib (INK1197， IPI-145）是磷脂酰肌醇-3激酶（PI3K）和 p100δ的选择性抑制剂，能够作用于 p110δ (IC50值为0.0025 μM)、p110γ (IC50值为0.274 μM)、p110β (IC50值为0.85 μM) 和 p110α (IC50值为1.602 μM)。

Elenbecestat,also known as E2609 is a BACE1 inhibitor. By inhibiting BACE, a key enzyme in the production of Aβ peptides, E2609 decreases the formation of these peptides which can aggregate into toxic oligomers and protofibrils and eventually form amyloid plaques in the brain. Elenbecestat has been shown to reduce Aβ levels in cerebrospinal fluid, was investigated in two global phase 3 studies in early AD.

MI-14 is a potent and selective inhibitor of PI 4-K IIIß.