phikan 083 hydrochloride

PhiKan 083 hydrochloride is a carbazole derivative. Which binds to the surface cavity and stabilizes Y220C (Kd: 167 μM). It also a relative binding affinity (Kd) of 150 μM in Ln229 cells.

PhiKan 083 是咔唑衍生物，可以稳定p53的突变体Y220C，Kd 值为 167 μM。它可用于癌症研究。