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Tozasertib lactate is a potent and selective small-molecule inhibitor of the Aurora kinases which suppresses tumor growth by inducing apoptosis in tumor cells in which Aurora kinases are overexpressed.

Tozasertib (MK-0457) 是一种 Aurora A/B/C 激酶抑制剂，Ki 值分别为 0.6、18和4.6 nM。它显示出对 190 多种不同激酶的选择性。