pd149163

SMTIN-P01 is a mitochondria-targeted Hsp90 inhibitor. It is made from the isopropyl amine of the Hsp90 inhibitor PU-H71 being replaced with the mitochondria-targeting moiety triphenylphosphonium.

PD-149163 is a selective, brain penetrating Neurotensin NTR1 receptor agonist. Neurotensin agonists block the pre-pulse inhibition deficits produced by a 5-HT2A and an α1 agonist. As a result, PD-149163 shows pro-cognitive, anti-psychotic and anxiolytic effects.

PD-149163 hydrochloride 是一种神经降压素激动剂，具有抗精神病活性，可调节小鼠模型细菌内毒素脂多糖诱导的神经炎症，可用于研究神经系统疾病。

Lipopolysaccharides, from E. coli O26:B6 是源自大肠杆菌 (E. coli) 的脂多糖内毒素和 TLR-4 激活剂，这种 S 型 LPS 可以激活免疫系统的病原相关分子模式 (PAMP) 并引导细胞分泌迁移体。它具有典型的三部分结构：O 抗原 (O-antigen)、核心寡糖 (core oligosaccharide) 和脂质 A (Lipid A)，此结构能够被核心特异性单克隆抗体 MAb J8-4C10 所识别。Lipopolysaccharides, from E. coli O26:B6 能促进血浆中的促炎细胞因子增加，从而引发下丘脑-垂体-肾上腺 (HPA) 轴的激活，导致肾上腺氧化损伤。PD149163 (HY-123434) 可阻断 Lipopolysaccharides, from E. coli O26:B6 的致病作用。