pcs-1055

PCS1055 dihydrochloride is an effective, selective, and competitive muscarinic M4 receptor antagonist (IC50: 18.1 nM and a Kd: 5.72 nM). PCS1055 dihydrochloride is also a potent AChE inhibitor (IC50 s: 22 nM and 120 nM for electric eel and human AChE, res

PCS1055 是一种毒蕈碱型M4受体 (muscarinic M4 receptor) 的选择性与竞争性拮抗剂，具有IC50值为18.1 nM 和 Kd值为5.72 nM。此化合物能够抑制放射性配体 [3H]-NMS 与 M4 受体的结合，显示出Ki值为6.5 nM。PCS1055 同时具备AChE抑制活性，对电鳗和人类AChE的IC50分别是22 nM和120 nM。