p110δ-in-1

P110δ-IN-1 (PWT-143) 是一种有效的、选择性的P110δ抑制剂，其 IC50=8.4 nM。

Alpelisib hydrochloride (BYL-719 hydrochloride) shows antineoplastic activity[1][2]. Alpelisib hydrochloride (BYL-719 hydrochloride) is a potent, orally active, and selective PI3Kα inhibitor with IC50s of 5 nM, 250 nM, 290 nM and 1200 nM for p110α, p110γ,

PI3K-IN-51, characterized as a PI3K inhibitor, exhibits IC50 values below 500 nM for p120γ and p110δ p85α (WO2016204429A1; Example 10) [1].