otx015

Birabresib (MK-8628) 是一种 BRD2 3 4抑制剂，IC50值为 92 到 112 nM 之间，具有潜在的抗肿瘤活性。

IDN-1965 is a potent, broad-spectrum, irreversible caspase inhibitor. IDN-1965 is markedly effective at inhibiting Fas-mediated apoptosis by multiple routes of administration. The therapeutic potential of caspase inhibitors appears promising for the treatment of apoptosis-mediated liver injury based on potency and postinsult efficacy.