2-Aminotetralin acts as a neuromodulatory agent by inhibiting serotonin (5-HT) and norepinephrine reuptake in the rat brain at a dose of 39.4 mg kg. It triggers hypothermia in rats through intracisternal or intraperitoneal injection, while the implantation of crystals in the hypothalamus' medial preoptic area leads to hyperthermia. Additionally, it mimics (+)-amphetamine in a two-lever drug discrimination test among rats in a dose-dependent manner.
Ampullosporin A 是一种从真菌Sepedonium ampullosporum HKI-0053中分离出的peptaibol型多肽,具有神经阻滞剂样作用。它能够抑制NMDA受体拮抗剂MK-801诱导的多动症,并改善亚慢性氯胺酮处理引起的社交行为异常。同时,Ampullosporin A 可以改变谷氨酸受体的活性,而对多巴胺D1和D2受体没有影响。