nafenodone

Nafenodone 是一种抗抑郁剂，能够降低心脏收缩的频率和幅度，并延长窦房结恢复时间。在离体大鼠血管平滑肌实验中，Nafenodone 可抑制门静脉节段的自发机械活动，其IC50为1.4 μM。此外，它还能松弛由高浓度K+和去甲肾上腺素引起的收缩。

Dexnafenodone Free Base is a potent inhibitor of noradrenaline, and to a lesser degree of serotonin reuptake, induced changes in the pattern of sleep which are comparable to those of non‐sedating tricyclic antidepressants.

Dexnafenodone Hydrochloride is an adrenergic receptor antagonist and serotonin uptake inhibitor.