nafamostat

Nafamostat是一种合成丝氨酸蛋白酶抑制剂，也是一种血液透析的抗凝血剂，通过上调TNFR1的表达诱导细胞凋亡，通过阻断 IκBα磷酸化抑制NF-κB 活性,能够抑制SARS-CoV-2和COVID-19。

Nafamostat mesylate (FUT-175) 是一种广谱丝氨酸蛋白酶抑制剂，血管舒缓素抑制剂，能抑制血液凝固。它通过降低颗粒酶活性和 CTL 细胞溶解抑制T 细胞自身反应活性，可抑制SARS-CoV-2 的激活。它还是潜在的补体抑制剂。

Nafamostat hydrochloride is a synthetic serine protease inhibitor and is an anticoagulant.

Sepimostat dimethanesulfonate (FUT-187) exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat dimethanesulfonate inhibits the Ifenprodil binding with a Ki value of 27.7 μM[1]. Sepimostat (1 to 100 nmol eye, intravitreal injection) exhibits significant neuroprotective effect[1]. Animal Model: Male Sprague Dawley rats weighing 150-300 g[1]. [1]. Masahiro Fuwa, et al. Nafamostat and Sepimostat Identified as Novel Neuroprotective Agents via NR2B N-methyl-D-aspartate Receptor Antagonism Using a Rat Retinal Excitotoxicity Model. Sci Rep. 2019 Dec 31;9(1):20409.