mk825

SR-1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR). It is an inverse agonist of RORγ and an agonist of LXR. It also binds to peroxisome proliferator-activated receptor γ (PPAR) but does not activate it. SR-1903 inhibits LPS-induced expression of triggering receptor expressed on myeloid cells 1 (TREM-1). It also inhibits LPS-induced expression of the LXR target genes IL-6 and IL-33 and increases expression of ABCG1, FASN, and SCD-1. SR-1903 reduces the severity of collagen-induced arthritis. It reduces blood glucose levels in a glucose tolerance test, serum levels of total cholesterol and LDL, body weight, and fat mass in a mouse model of high-fat diet-induced obesity.

MK-825盐酸半乙酸乙酯是一种CETP抑制剂。

MK-825 is a cholesteryl ester transfer protein (CETP) inhibitor.

Golimumab (CNTO-148) 是一种有效的人源化抗 TNFα IgG1κ单克隆抗体 。Golimumab 具有抗炎和抗癌活性，对 IL-6 和 IL-1β 的产生有抑制作用，可诱导细胞凋亡。Golimumab 可用来预防炎症发生和软骨或骨骼的破坏，可用于研究类风湿性关节炎和癌症。