malpeg4va

Mal-PEG4-VA, a noncleavable ADC linker featuring a Maleimide group, is utilized in the synthesis of antibody-drug conjugates.

Mal-PEG4-Val-Cit-PAB-OH, a cleavable 4-unit PEG ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs)[1].

Mal-PEG4-Val-Cit-PAB-PNP is a cleavable 4-unit polyethylene glycol (PEG) linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].

Mal-PEG4-VA-PBD是一种抗体偶联药物（ADC）中常用的连接子-毒素复合结构，Mal与抗体巯基偶联，PEG4作为亲水间隔臂提高溶解性，VA为可被溶酶体蛋白酶切割的二肽连接子，以及吡咯并苯二氮卓（PBD）DNA烷化剂作为细胞毒载荷组成。Mal-PEG4-VA-PBD可在进入细胞后经蛋白酶裂解释放PBD，从而与DNA形成共价加合物并诱导细胞死亡。

Mal-PEG4-Val-Cit-PAB, a cleavable ADC linker incorporating a Maleimide moiety, finds application in the construction of antibody-drug conjugates (ADCs)[1].

Mal-PEG4-Val-Cit-PAB-MMAE是抗体偶联活性分子ADC的linker-payload部分，由可降解的ADC linker和微管蛋白抑制剂MMAE组成。