lypla2

3-Chlorophenylboronic acid 是苯硼酸类衍生物,是合成脯氨酰羟化酶抑制剂的重要中间体，可用于合成多种化合物。3-Chlorophenylboronic acid 对溶血磷脂酶LYPLA2的IC50为0.418 µM。

ML-211 是基于氨基甲酸酯的酰基蛋白硫酯酶1 溶血磷脂酶1 (IC50=17 nM) 和LYPLA2(IC50=30 nM) 的双重抑制剂。它能够抑制丝氨酸水解酶ABHD11 (IC50=10 nM)，但在 20 个丝氨酸水解酶组合中，对 LYPLA 的选择性为 50 倍。

ML349 是一种特异性酰基蛋白硫酯酶 2 溶血磷脂酶 2 抑制剂，其Ki=120 nM。它也是一种 LYPLA2的抑制剂，其IC50=144 nM。

JJH260 is an N-hydroxy hydantoin carbamate that inhibits androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). It blocks the hydrolysis of 9-PAHSA with an IC50 value of 0.57 μM. JJH260 also inhibits the novel FAHFA hydrolase androgen-dependent TFPI-regulating protein (ADTRP; IC50 = 8.5 μM), as well as the serine hydrolase ABHD6 and the lysophospholipases LYPLA1 and LYPLA2. JJH260 inhibits the FAHFA hydrolase activity of LNCaP and T cell lysates and intact cells.