Ligustrazine Hydrochloride, is a natural substance discovered in the plant Ligusticum chuanxiong Hort. It inhibits platelet aggregation, improves atherosclerosis situation, protects endothelium injury, and has antithrombotic effects.in vivo,ligustrazine hydrochloride at 10 and 20 mg kg produced significant analgesic effects against mechanical stimuli,and ligustrazine hydrochloride at 80 mg kg, also significantly alleviated cold hypersensitivity manifested by reduction in cold vocalization temperature.