leupeptin

Leupeptin is a competitive protease inhibitor produced by actinomycetes. Leupeptin can inhibit cysteine, serine and threonine peptidases. Leupeptin inhibits serine proteinases (trypsin (Ki=3.5 nM), plasmin (Ki= 3.4 nM), porcine kallikrein), and cysteine p

Leupeptin hemisulfate 是一种蛋白酶抑制剂，具有细胞膜渗透性、可逆性、竞争性和口服活性。Leupeptin hemisulfate 可以抑制 Cathepsin B、Cathepsin H、Cathepsin L 的活性，阻断两性溶酶体的融合。Leupeptin hemisulfate 还具有抗炎活性。

Leupeptin is a naturally occurring protease inhibitor that can inhibit cysteine, serine and threonine peptidases. Leupeptin is an organic compound produced by actinomycetes. Leupeptin inhibits serine proteinases (trypsin (Ki=3.5 nM), plasmin (Ki= 3.4 nM), porcine kallikrein), and cysteine proteinases (papain, cathepsin B (Ki = 4.1 nM), endoproteinase Lys-C). It does not inhibit α-chymotrypsin or thrombin. Leupeptin is a competitive transition state inhibitor and its inhibition may be relieved by an excess of substrate.

Leupeptin Ac-LL(hydrochloride)为Leupeptin Ac-LL的盐酸盐版本，具备比Leupeptin Ac-LL更优异的抑制性能。

Leupeptin acid is an enzyme.

NC-002是一种细胞穿透肽，作为胰蛋白酶样蛋白酶体 (Trypsin-like proteasome) 抑制剂，不影响溶酶体半胱氨酸蛋白酶的活性。它是Leupeptin的环氧酮衍生物，能够提高骨髓瘤细胞对Bortezomib和Carfilzomib的敏感性。NC-002适用于癌症研究。