k145

K145 is inactive against SphK1 and other protein kinases. K145 induces cell apoptosis and has potently antitumor activity. K145 is a selective, substrate-competitive and orally active SphK2 inhibitor with an IC50 of 4.3 µM and a Ki of 6.4 µM.

K145 hydrochloride 是选择性的，底物竞争性的和口服有效的SphK2抑制剂，IC50为 4.3 µM，Ki 为 6.4 µM。它可诱导细胞凋亡，显示出强大的抗肿瘤活性。

Ulevostinag isomer 2 (MK-1454 isomer 2) 是 Ulevostinag 的一种异构体，其为STING激动剂。

Ulevostinag (isomer 3) (example 246) 是一种强效的干扰素基因 (STING) 环状二核苷酸激动剂。其在抗肿瘤研究中具有重要作用。

Ulevostinag isomer 4 (MK-1454 isomer 4) 是 Ulevostinag 的一个异构体，Ulevostinag 是一种 STING 激动剂。

K-14585 is a proteinase-activated receptor 2 antagonist. K-14585 inhibited PAR(2)-mediated p65 NFkappaB phosphorylation and NFkappaB-DNA binding. K-14585 inhibited SLIGKV-stimulated IL-8 production, but given alone increased IL-8.

Ulevostinag (MK-1454) is a STING agonist.