junin

ST-193 hydrochloride is a potent inhibitor of broad-spectrum arenavirus(Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively).

ST-193是一种 arenavirus 的广谱抑制剂。它抑制 Guanarito, Junin, Lassa 和 Machupo 病毒的 IC50值分别为0.44, 0.62, 1.4 和3.1 nM。

(E)-LHF-535 是 LHF-535 的E 异构体， LHF-535 是一种抗病毒剂，对 Lassa，Machupo，Junin，VSVg 病毒的 EC50分别为 <1 μM，<1 μM，<1 μM 和 1-10 μM。

LHF-535 是一种抗病毒剂，对 Lassa，Machupo，Junin，VSVg 病毒的 EC50分别为 <1 μM，<1 μM，<1 μM 和 1-10 μM

ST-193 hydrochloride 是有效的广谱arenavirus 抑制剂。ST-193 hydrochloride 抑制Guanarito, Junin, Lassa 和Machupo 病毒，IC50分别为0.44, 0.62, 1.4 和3.1 nM。

Verrucarin J (Muconomycin B) 是Myrothecium 真菌家族的代谢物。Verrucarin J 诱导活性氧 (ROS) 生成和癌细胞系凋亡 (apoptosis)，例如 A549、HCT 116 和 SW-620 细胞。Verrucarin J 具有抗Candida albicans 和Mucor miehei 的活性。Verrucarin J 抑制沙粒病毒 Junin (JUNV) 产量，IC50为 1.2 ng mL。

EICAR is a drug which acts as an inhibitor of the enzyme IMP dehydrogenase. It is a nucleoside derivative which has both anti-cancer and antiviral effects, and was originally developed for the treatment of leukemia, but was unsuccessful in human clinical trials. It has broad spectrum antiviral effects with activity against vaccinia virus, Semliki forest virus, Junin virus, reovirus, influenza, measles virus and respiratory syncytial virus among others, although it is not active against SARS. This useful spectrum of activity means that EICAR and related derivatives continue to be investigated for the treatment of viral diseases.

ATP-γ-S tetrasodium (Adenosine-5'-O-(3-thiotriphosphate) tetrasodium) 是一种 purinergic P2Y11 受体激动剂，也是 ATP 类似物，可诱导肌醇磷酸累积，诱导 MIN6 胰岛 β 细胞分泌胰岛素，可诱导细胞内钙浓度增加。ATP-γ-S tetrasodium 抑制 Junin 病毒诱导的编码骨形态生成蛋白6（BMP6）的 mRNA 水平增加，可减少 Junin 病毒感染的初代大鼠成骨细胞中的粒子形成单位（PFUs）。