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  • 抑制剂&激动剂
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    TargetMol | Inhibitors_Agonists
  • Zolmitriptan
    佐米曲普坦, BW-311C90, 311C90
    T1092139264-17-8
    Zolmitriptan (311C90) 是一种5-HT1B 1D 受体部分激动剂,可用于偏头痛的研究,对 5-HT1B、5-HT1D、5-HT1F 受体的Ki 分别为 5.01、0.63 和 63.09 nM。
    • ¥ 327
    In stock
    规格
    数量
  • UCL 2077
    T17197918311-87-2
    UCL 2077 是癫痫相关 KCNQ 通道的亚型选择性阻滞剂,也是一种选择性慢后超极化通道阻滞剂,在培养的海马神经元中 IC50 为 500 nM,对 Ca2+ 通道、动作电位、输入电阻的影响小 ,以及超极化后的介质。
    • ¥ 286
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • NLCQ-1 HCl
    NLCQ-1 hydrochloride, NLCQ1 HCl, NSC 709257
    T33699221292-08-6
    NLCQ-1 is a novel weak DNA-intercalative bioreductive compound. NLCQ-1 exhibited a C50 of 44 microM. NLCQ-1 demonstrated significant hypoxic selectivity in several rodent (V79, EMT6, SCCVII) or human (A549, OVCAR-3) tumor cell lines. Its potency as a hypo
    • ¥ 10600
    6-8周
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    数量
  • PSEM 308 hydrochloride
    T37391
    PSAM (pharmacologically selective actuator module) agonist. Activates PSAML141F-GlyR chimeric ion channels. Inhibits activity of neurons expressing PSAML141F-GlyR in vivo and activates locus coeruleus noradrenergic neurons expressing PSAML141F,Y115F-5-HT3 ion channels. Recommended concentration for use in mice is 5 mg kg or lower. Plasmid vectors for the transfection of cells with PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 are available from Addgene. Lovett-Barron et al (2012) Regulation of neuronal input transformations by tunable dendritic inhibition. Nat.Neurosci. 15 423 PMID:22246433 |Satoh et al (2016) Context-dependent gait choice elicited by EphA4 mutation in Lbx1 spinal interneurons. Neuron 89 1046 PMID:26924434 |Atasoy et al (2012) Deconstruction of a neural circuit for hunger. Nature 488 172 PMID:22801496 |Hirschberg et al (2017) Functional dichotomy in spinal- vs prefrontal-projecting locus coeruleus modules splits descending noradrenergic analgesia from ascending aversion and anxiety in rats. Elife 6 e29808 PMID:29027903
    • 待估
    35日内发货
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  • GRC-6211
    T713491166398-35-1
    GRC-6211 is an oral specific TRPV1 antagonist which decreases bladder overactivity and noxious bladder input in cystitis animal models.
    • ¥ 10600
    6-8周
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    数量