hti-286 hydrochloride

Taltobulin hydrochloride is a synthetic analogue of the tripeptide hemiasterlin, is a potent agent of antimicrotubule that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.

Taltobulin hydrochloride (HTI-286 hydrochloride) 是一种合成的三肽半胱氨酸类似物，为高效抗微管剂，能够在体内外绕过P-糖蛋白介导的药物耐药性。该化合物通过抑制微管蛋白的聚合和破坏细胞内微管结构，进而引起细胞有丝分裂停滞和细胞凋亡。