CBS1194 is a novel antiviral agent against influenza A virus (IAV), and is more specifically, a group 2 IAV fusion inhibitor. CBS1194 prevents membrane fusion of the virus through the inhibition of the conformational change of hemagglutinin (HA). CBS1194 causes steric hinderance that prevents the rearrangement of the HA that would normally be induced by low-pH, by fitting into the pocket by the fusion peptide.
Hyaluronan-binding peptide, biotin labeled 是通过 C 端 GGGSK 残基生物素化的透明质酸结合肽,能够干预 HA 与 CD44 受体的作用,并阻碍 T 细胞增殖。 HA 在细胞外基质和细胞表面广泛表达,参与多种生物过程,包括受精、胚胎发育、伤口修复、血管新生、炎症反应和肿瘤转移。
3X HA Tag(Triple-HA Tag)是一种生物活性肽,由三个重复的 HA 标签(YPYDVPDYA)通过肽键连接而成,主要用于蛋白质和肽的检测以及促进目标蛋白质的功能分析。3X HA Tag 可以被抗 HA 标签的抗体特异性识别和结合,广泛应用于 Western blot、免疫荧光、免疫沉淀等实验技术。
HA-14-1, a small molecule, binds the surface pocket of Bcl-2 proteins (IC50= ~ 9 µM), including Bcl-xl and Bcl-W, and disrupts their interaction with the Bak peptide. This action induces apoptosis by activating Apaf-1 and caspase-9 and -3. Additionally, HA-14-1 effectively induces apoptosis in human acute myeloid leukemia (HL-60) cells, with a 50 µM concentration resulting in a 90% loss of cell viability.
Influenza HA (126-138) is a peptide derived from the hemagglutinin (HA) protein of the influenza virus. It consists of amino acids 126-138 and has the ability to induce apoptosis in both thymic and peripheral T-cells.
Hyaluronan-binding peptide, biotin labeled TFA 是一种具有生物活性的肽。(该肽通过 C 端 GGGSK 连接体实现生物素化,是透明质酸结合肽。透明质酸 (HA) 是在细胞外基质和细胞表面发现的非硫酸化糖胺聚糖。 HA 在受精、胚胎发育、伤口愈合、血管生成、白细胞向发炎组织运输和癌症转移中起作用。该肽已被证实可以阻断 HA 与 CD44 受体的结合并抑制 T 细胞增殖。)