glun1/glun2d

(RS)-(Tetrazol-5-yl)glycine 是一种高效且选择性的 N-甲基-D-天冬氨酸 (NMDA) 受体激动剂，能够诱导小鼠癫痫发作模型和 Fos 的表达。它对 GluN1/GluN2D 和 GluN1/GluN2A 的 EC50 分别为 99 nM 和 1.7 μM。

UBP608 is an allosteric modulator of NMDA receptor family. It selectively inhibits GluN1/GluN2A receptors with a 23-fold selectivity compared to GluN1/GluN2D receptors.

(3S,6R)-NML 是一种 NMDA 受体拮抗剂，pIC50值为 4.8 (GluN1-GluN2A)、4.6 (GluN1-GluN2B)、5.0 (GluN1-GluN2C) 和 5.0 (GluN1-GluN2D)。(3S,6R)-NML 适用于抑郁症的研究。

NSC339614 potassium is a selective GluN1/GluN2C and GluN1/GluN2D receptors potentiator.

NAB-14 is a powerful and selective chemical compound that acts as a non-competitive antagonist for GluN2C and GluN2D receptors. With an IC50 value of 580 nM for GluN1/GluN2D, NAB-14 demonstrates high potency. This compound exhibits a remarkable selectivity of more than 800-fold towards recombinant GluN2C and GluN2D when compared to GluN2A and GluN2B. Furthermore, NAB-14 possesses the ability to penetrate the blood-brain-barrier effectively [1].