galanthamine

Galanthamine (Galantamine) 是一种乙酰胆碱酯酶抑制剂，IC50为 500 nM。

Galanthamine hydrobromide (Galantamine hydrobromide) 是一种长效的中枢活性 AChE 抑制剂，IC50为 410 nM。它是神经元烟碱型 ACh 受体的变构增强剂，IC50值为 0.35 µM，可用于阿尔茨海默症的研究。

Lycoramine 是一种加兰他敏的二氢衍生物，从Lycoris radiate 中分离得到，是一种乙酰胆碱酯酶抑制剂。

Galanthamine N-Oxide 是分离于Zephyranthes concolor 的球茎中的一种生物碱。它抑制电鳗乙酰胆碱酯酶，EC50=26.2 μM。它是TcAChE，hAChE 和 hBChE 酶活性位点中底物调节的显著抑制剂。

Galanthamine-O-methyl-d3 是 Galanthamine-O-methyl 的氘代化合物。Galanthamine-O-methyl 的 CAS 号为 357-70-0。Galanthamine 是一种乙酰胆碱酯酶抑制剂，IC50为 500 nM。

O-Desmethyl Galanthamine (Sanguinine) 是一种加兰他敏型生物碱，是一种乙酰胆碱酯酶 (AChE) 抑制剂, 其IC50=1.83 μM。

N-Desmethyl Galanthamine 在生命科学相关研究中具有广泛的应用。

O-Acetylgalanthamine 是一种天然产物，已在 Narcissus pseudonarcissu 的鳞茎中发现。

P11149 is a competitive, BBB-penetarated weakly, orally active and selective inhibitor of AChE. P11149 exhibits an IC50 of 1.3 μM for rat BChE AChE. P11149, a Galanthamine derivative, demonstrates central cholinergic activity, behavioral efficacy and safety. P11149 is used in the study for Alzheimer’s disease[1]. P11149 is a GAL analog that is rapidly hydrolyzed in vivo to yield the potent AChE inhibitor, 6-DMG[1].P11149 exhibits greater s.c. bioavailability than p.o. [1].Oral P11149 in mice produces Sal, Lac and tremors at doses similar to those in rats, whereas 6-DMG, P1 1012 and GAL produces Sal and Lac at doses lower than those in rats[1].P11149 exhibits T1 2(el) of 2.4 h and Cmax of 585 ng mL in rat plasma[1]. [1]. G M Bores, et al. Pharmacological evaluation of novel Alzheimer’s disease therapeutics: acetylcholinesterase inhibitors related to galanthamine. J Pharmacol Exp Ther. 1996 May;277(2):728-38.

Dihydronarwedine is a metabolite of Galanthamine, an inhibitor of glycogen synthase kinase 3β (GSK3β)