Spexin TFA, a potent agonist for galaninreceptor 2 3 (GAL2 GAL3) with EC50 values of 45.7 and 112.2 nM respectively, shows no significant activity towards galaninreceptor 1. As an endogenous peptide promoting satiety, it reduces long chain fatty acid uptake by adipocytes and lowers food consumption in diet-induced obese mice and rats. Additionally, it moderates LH secretion in goldfish and demonstrates anxiolytic effects in vivo.
Potent galaninreceptor 2 3 (GAL2 GAL3) agonist (EC50 values are 45.7 and 112.2 nM, respectively). Exhibits no significant activity at galaninreceptor 1. Endogenous satiety-inducing peptide; inhibits long chain fatty acid uptake by adipocytes and decreas