g 18

KRAS G12C inhibitor 18 is a potent, orally active compound that inhibits KRAS G12C and exhibits anti-tumor activities.

C18G为源自人血小板因子IV的合成α-螺旋肽，具备生物活性。研究表明，C18G显示出抗菌效果，尤其对沙门氏菌有活性。

G7-18NATE 是 Grb7 的肽抑制剂，以微摩尔亲和力 (KD= 18.1 μM) 结合 Grb7-SH2 结构域，可抑制多种癌细胞系的细胞增殖、运动、细胞侵袭和 3D 培养物形成。

G7-18NATE TFA 作为Grb7的肽类抑制剂,与 Grb7-SH2结构域具有微摩尔级别的亲和性 (KD = 18.1 μM).此化合物能够抑制多种癌细胞系的增殖、迁移、侵袭以及在3D培养中的形成.

AG-1812 is a bio-active chemical.

HPG1860, 作为法尼酮X受体(FXR)的激动剂，在使用表达人类FXR的HEK293T细胞的报告基因检测中能引发发光（EC50 = 18 nM）。动物体内实验显示，HPG1860（每天1、3、或10 mg kg）可以减少非酒精性脂肪性肝炎（NASH）小鼠模型的血清谷丙转氨酶（ALT）和总胆固醇水平，该小鼠模型是通过高脂饮食和四氯化碳（CCl4）诱导的。此化合物还能降低肝部的炎症、脂肪积累及纤维化。

Tyrphostin 23 (AG18) 是一种EGFR 抑制剂，IC50值为35 μM。

(Z)-Tyrphostin A51 是 Lanoconazole A51 的 Z 构型形式。Tyrphostin A51 是一种有效的蛋白酪氨酸激酶 (PTK)抑制剂，以剂量依赖性方式抑制原代星形胶质细胞培养物中 [3H]牛磺酸的体积敏感释放。Tyrphostin A51 显着降低细胞酪氨酰磷酸化水平。Tyrphostin A51 抑制基础和 EGF 诱导的人骨细胞增殖。

Bis-propargyl-PEG18 is a crosslinker containing two propargyl groups at each terminal end.

AG-1859, an HIV protease inhibitor, is used potentially for the treatment of HIV infection.

AG-1801 is a bio-active chemical.

ABT-1812 is a bio-active chemical.

STING18 is a competitive ligand of stimulator of interferon genes (STING; IC50 = 0.068 μM in a radioligand binding assay).1 It inhibits cGAMP-induced IFN-β production (IC50 = 11 μM) but does not stimulate IFN-β production (EC50 = >30 μM) in THP-1 cells. |1. Siu, T., Altman, M.D., Baltus, G.A., et al. Discovery of a novel cGAMP competitive ligand of the inactive form of STING. Med. Chem. Lett. 10(1), 92-97 (2019).

GLPG1837 (ABBV-974) 是一种有效的 CFTR 增强剂，对其 F508del 和 G551D 的 EC50 分别为 3 nM 和 339 nM。

Abrilumab (MEDI-7183) 是一种抗 α4β7 的完全人类单克隆抗体，抑制 α4β7 整合素，可用于研究炎症性肠病和溃疡性结肠炎。

SB1-G-187为PROTAC化合物，属于多激酶降解剂类。

Yimitasvir (Emitasvir) diphosphate是一口服活性HCV NS5A抑制剂，适用于研究慢性丙型肝炎病毒感染。

PAF C-18（十八烷 PAF）是一种天然存在的磷脂类分子，属于血小板活化因子（PAF）家族,作为细胞间信号传导分子，涉及血小板聚集、血管扩张和炎症反应。PAF C-18通过与其特异性G蛋白偶联受体（PAFR）结合参与止血和血栓形成过程，是内源性激动剂。

PPO-IN-18 (Compound g13) 是一种原卟啉原氧化酶（PPO）抑制剂，可有效抑制稗草PPO（EcPPO），其IC50为0.109 μM。PPO-IN-18 对稗草、牛筋草、稷、牵牛、藜和苘麻具有除草活性，在150-300 g ai ha的剂量下，对作物没有显著毒性。

Grayanotoxins are a group of closely related neurotoxins named after Leucothoe grayana. Extract from leaves of Ericaceae.

17(R)-Protectin D1 is an aspirin-triggered epimer of the specialized pro-resolving mediator protectin D1 .1It decreases leukotriene B4-induced transendothelial migration of human polymorphonuclear (PMN) neutrophils when used at concentrations ranging from 0.1 to 10 nM. 17(R)-Protectin D1 (0.01-10 ng) reduces the recruitment of neutrophils in a mouse model of TNF-α-induced peritonitis. 1.Serhan, C.N., Fredman, G., Yang, R., et al.Novel proresolving aspirin-triggered DHA pathwayChem. Biol.18(18)976-987(2011)

17R(18S)-EpETE is an oxylipin and a cytochrome P450 metabolite of eicosapentaenoic acid .1,217R(18S)-EpETE is an activator of large-conductance calcium-activated potassium (BKCa) channels, increasing the potassium current amplitude by 15-fold in isolated rat cerebral artery vascular smooth muscle cells (VSMCs) at +60 mV when used at a concentration of 50 nM.2It has negative chronotropic effects in isolated neonatal rat cardiomyocytes (NRCMs; EC50= ~1-2 nM) and prevents calcium-induced increases in the spontaneous beating of NRCMs.3,4 1.Schwarz, D., Kisselev, P., Ericksen, S.S., et al.Arachidonic and eicosapentaenoic acid metabolism by human CYP1A1: Highly steroselective formation of 17(R), 18(S)-epoxyeicosatetraenoic acidBiochem. Pharmacol.67(8)1445-1457(2004) 2.Lauterbach, B., Barbosa-Sicard, E., Wang, M.H., et al.Cytochrome P450-dependent eicosapentaenoic acid metabolites are novel BK channel activatorsHypertension39(2 Pt. 2)609-613(2002) 3.Falck, J.R., Wallukat, G., Puli, N., et al.17(R),18(S)-Epoxyeicosatetraenoic acid, a potent eicosapentaenoic acid (EPA) derived regulator of cardiomyocyte contraction: Structure-activity relationships and stable analoguesJ. Med. Chem.54(12)4109-4118(2011) 4.Arnold, C., Markovic, M., Blossey, K., et al.Arachidonic acid-metabolizing cytochrome P450 enzymes are targets of omega-3 fatty acidsJ. Biol. Chem.285(43)32720-32733(2010)

Endosulfan I is an organochlorine insecticide and a stereoisomer of endosulfan II . It is active against a variety of insects, including bollworms (LD50 = 0.63 mg/g). Endosulfan I binds to GABA receptors in rat brain membranes with an IC50 value of 30 nM and is toxic to rats (LD50 = 18 mg/kg).

GRK6-IN-1 是一种具有选择性和高效性的 G 蛋白偶联受体激酶 6 (GRK6) 抑制剂（IC50：120 nM）。GRK6-IN-1 具有研究多发性骨髓瘤和三阴性乳腺癌。