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Anti-ATG18 Antibody (8B338)

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货号 TMAB-02915

Anti-ATG18 Antibody (8B338) 是一种 Rabbit 抗体，靶向 ATG18。Anti-ATG18 Antibody (8B338) 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-ATG18 Antibody (8B338)

Anti-ATG18 Antibody (8B338)

一键复制产品信息
Rating icon 还可以
货号 TMAB-02915

Anti-ATG18 Antibody (8B338) 是一种 Rabbit 抗体，靶向 ATG18。Anti-ATG18 Antibody (8B338) 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
25 μL
¥ 795
5日内发货
50 μL
¥ 1,385
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

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产品描述
Anti-ATG18 Antibody (8B338) is a Rabbit antibody targeting ATG18. Anti-ATG18 Antibody (8B338) can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
克隆号
8B338
反应种属
Human,Mouse,Rat
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-200; IHC-Fr: 1:100-200; IF: 1:100-200
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Golgi apparatus, trans-Golgi network. Endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Preautophagosomal structure membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Trans elements of the Golgi and peripheral endosomes. Dynamically cycles through these compartments and is susceptible to conditions that modulate membrane flux. Enriched in clathrin-coated vesicles. Upon starvation-induced autophagy, accumulates at subcellular structures in the cytoplasm: enlarged vesicular and lasso-like structures, and large cup-shaped structures predominantly around the nucleus. Recruitment to autophagic membranes is controlled by MTMR14. Labile microtubules specifically recruit markers of autophagosome formation like WIPI1, whereas mature autophagosomes may bind to stable microtubules.
组织特异性Ubiquitously expressed. Highly expressed in skeletal muscle, heart, testis, pancreas and placenta. Highly expressed in G361, Sk-mel-28, Sk-mel-13, WM852 and WM451 cells. Up-regulated in a variety of tumor tissues.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation.
抗原信息
免疫原
A synthesized peptide: human WIPI 1
抗原种属
Human
基因名称
WIPI1
基因ID
55062
蛋白名称
WD repeat domain phosphoinositide-interacting protein 1
Uniprot ID
Q5MNZ9
功能
Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway.
化学信息
分子量Theoretical: 49 kDa. Actual: 48 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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