fluprostenol methyl ester

Fluprostenol is an F-series prostaglandin analog which has been approved for many years as a luteolytic in veterinary animals. The isopropyl ester of fluprostenol (travoprost) is an effective ocular hypotensive drug. CAY10532 is a methyl ester analog of fluprostenol.

AL 8810 methyl ester为前列腺素F(2α)类似物，充当前列腺素F(2α)受体激动剂，能够与FP受体激动剂Fluprostenol进行竞争性拮抗。AL 8810 methyl ester在细胞系中对TP、DP、EP(2)、EP(4)受体亚型不具备明显效力。