ferroptosis inhibition

TOFA-Plasmalogen (compound 1) 为一种具有诱导铁死亡 (ferroptosis) 活性的甘油醛衍生物。该化合物通过增强细胞膜脂质过氧化作用，展现出明显的细胞毒性，其半抑制浓度 (IC50) 为32.87 μM。

Pantothenate Kinase Inhibitor (PANKi) is a reversible inhibitor of pantothenate kinase (PanK; IC50s = 70, 92, and 25 nM for PanK1β, PanK2, and PanK3, respectively), the rate-limiting enzyme in the synthesis of coenzyme A .1It binds to the ATP-PanK3 complex with an apparent binding constant of 300 nM and exhibits mixed-type inhibition with respect to ATP and pantothenate. PANKi inhibits CoA biosynthesis in C3A cells (IC50= 0.9 μM) with no effect on cell viability when used at concentrations up to 8 μM. PANKi (5 μM) synergizes with BSO to induce ferroptosis in PANC-1 cells and sensitizes the cells to imidazole ketone erastin-induced ferroptosis.2 1.Sharma, L.K., Leonardi, R., Lin, W., et al.A high-throughput screen reveals new small-molecule activators and inhibitors of pantothenate kinasesJ. Med. Chem.58(3)1563-1568(2015) 2.Badgley, M.A., Kremer, D.M., Maurer, H.C., et al.Cysteine depletion induces pancreatic tumor ferroptosis in miceScience368(6486)85-89(2020)

IM-93 抑制铁死亡(ferroptosis)和 坏死(NETosis)，抑制细胞死亡的IC50值为 0.45 μM。

GPX4-IN-3 (26a) 作为一种有效的谷胱甘肽过氧化物酶4 (GPX4) 抑制剂，其能选择性诱导铁死亡（ferroptosis）。在1 μM浓度下，该化合物能抑制GPX4活性达71.7%。