esat 6

ESAT6 Epitope, 早期分泌抗原靶基因 6 (ESAT6) 中已知的 CD4+ T 细胞表位,其与主要组织相容性复合体 MHC I 类具有纳米级亲和力,IC50 值为180 nM.此表位可用于提升卡介苗引发的抗结核分枝杆菌细胞免疫反应.

Dimethyldioctadecylammonium (DDA) is a cationic amphipathic lipid. DDA liposomes containing an Ag85B-ESAT-6 antigen induce antigen deposition at an intramuscular or subcutaneous injection site in mice, increasing immune cell exposure to the antigen. In a guinea pig model of M. tuberculosis infection, spleen bacterial load is reduced and lung and spleen lesion numbers are decreased when the mycobacterial lipid antigens Ac2SGL and PIM2 are administered in liposomes comprised of DDA and a synthetic analog of the mycobacterial cord factor trehalose 6,6-dibehenate (TDB). DDA has also been used in the study of lipid bilayer dynamics.