e16

Gue1654 是一种选择性 OXE-R 抑制剂，通过激活 BCAT1 缓解冠状动脉结扎诱导的小鼠缺血性心肌损伤和心肌细胞氧 葡萄糖剥夺诱导的损伤。Gue1654 抑制 OXE-R 抑制的蛋白激酶 C-ε （PKC-ε） 核因子 κB （NF-κB） 信号传导和心肌细胞凋亡。Gue1654 可用于研究心血管疾病。

Drinabant (AVE-1625) 是具有口服活性的 CB1 受体的拮抗剂。Drinabant 抑制 hCB1-R 和 rCB1-R 激动剂刺激的钙信号的 IC50 分别为 25 nM 和 10 nM。对 hCB2-R 无活性。

JKE-1674 是口服有效的谷胱甘肽过氧化物酶 4 (GPX4)抑制剂，是ML-210的活性代谢物，可转换成丁腈氧化物 JKE-1777。JKE-1674 能用与 ML-210 相同的方式杀死 LOX-IMVI 细胞，并被ferroptosis 抑制剂完全挽救。

Desmopressin acetate (16679-58-6 free base) (DDAVP) 是抗利尿激素精氨酸加压素的合成类似物。

Myristoyl Hexapeptide-16 Acetate 被归类为一种蛋白质刺激肽，这意味着它可以帮助皮肤表面看起来更好，并且更能抵抗水分流失。

G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a Ki of 3.7 nM.

Cembratetraene-16,2:19,6-diolide 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T131083。

Hexadecenyl-2-hydroxy-sn-glycero-3-PC (C16(Plasm) LPC) 是一种磷脂酰胆碱，能够延长 α-syn 聚集的滞后期，适用于帕金森病的研究。

E3 LigaseLigand-linker Conjugate 161 是一种 E3 泛素酶配体-连接子偶联物 (E3ligaseligand-linker conjugate)，用于合成 Tamoxifen-PEG-Clozapine。

E3 Ligase Ligand-linker Conjugate 160 是一种 E3 泛素酶配体-连接子偶联物 (E3 Ligase Ligand-linker conjugate)，用于合成FF2049。

E3 Ligase Ligand-linker Conjugate 168 是一种由E3连接酶Cereblon的配体和连接子组合而成的化合物。它可用于合成PROTAC c-Met degrader-3。

E3 Ligase Ligand-linker Conjugate 163 是 AH078 的 E3 连接酶配体 (E3 Ligase Ligand 58)-连接子偶联物。AH078 是一种 PROTAC，旨在靶向降解 CK1δ 和 CK1ε，可用于研究昼夜节律失调相关的疾病。

E3 Ligase Ligand-linker Conjugate 166 是一种由 E3 连接酶配体和连接子组成的复合物，用于合成 PROTACCDK9degrader-11。

E3 Ligase Ligand-linker Conjugate 162 是 YW-N-7 (TFA) 的 E3 连接酶配体-连接子偶联物。YW-N-7 (TFA) 是一种用于靶向降解RET激酶的PROTAC，适用于癌症研究。

E3 Ligase Ligand-linker Conjugate 165 是包含 E3 连接酶配体及连接子的偶联化合物，用于合成PROTACS J44236。

PD-1/PD-L1 Inhibitor 3 acetate (1629654-95-0 Free base) 抑制人 PD-1 与 PD-L1 的结合，IC50 为 9 nM。

9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 (Meteneprost) is a potent analog of prostaglandin E2 with an extended half-life in vivo. In combination with various other prostaglandin derivatives, it results in the termination of first trimester pregnancy in monkeys. A single intramuscular injection containing 0.5 mg of meteneprost and 7.5 mg of 17-phenyl trinor PGF1α is very effective in terminating early pregnancy. This prostaglandin mixture is ineffective on monkeys in their third trimester of pregnancy. Meteneprost, when compared to PGE2 and PGF1α, in monkey and rat, does not result in unwanted side effects such as fever or gastrointestinal problems.

TAPI-1 trifluoroacetate 是一种 ADAM17 TACE 抑制剂，可阻断细胞因子受体的脱落。

BMS202 hydrochloride (1675203-84-5(free base)) (PD-1 PD-L1 inhibitor 2 hydrochloride) 是一种小分子 PD-1 PD-L1 相互作用抑制剂 (IC50: 18 nM)。生物物理研究表明 BMS202 直接与 PD-L1 结合。 BMS202 的结合促进 PD-L1 二聚化并阻断 PD-L1 PD1 相互作用。

D-Fructose-1,6-diphosphate trisodium salt octahydrate 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T65105。

ZWITTERGENT 3-16 Detergent 是一种季铵表面活性剂、乳化剂、发泡剂和润湿剂，常用于护肤品行业。ZWITTERGENT 3-16 Detergent 参与蛋白纯化。

Wnt signaling is required for direct multiple biological processes and also plays key roles in the pathogenesis of various diseases. Cyclic AMP response element-binding protein (CREB) is a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Via generating a transcriptionally active complex with β-catenin, CREB acts as a mediator of Wnt signaling.ICG-001 is an inhibitor of β-catenin CREB mediated transcription. The direct cellular target of ICG-001 is CREB. the inhibitory IC50of ICG-001 against β-catenin CREB mediated transcription was 3 μM. ICG-001 treatment at the concentration of 25 μM for 24h significantly increased caspase activity in both colon cancer cell lines SW480 and HCT116 cell lines but not in normal colonic epithelial cells CCD-841Co. In a cell growth inhibition assay, the IC50s of ICG-001 against SW480 and HCT116 cells were 4.43 μM and 5.95 μM, respectively.In a SW620 nude mouse xenograft model, an water-soluble analog of ICG-001 given at the dose of 150 mg kg i.v. once in every 2 days dramatically suppressed tumor growth. In a bleomycin-induced pulmonary fibrosis mice model, ICG-001 given at the dose of 5 mg kg per day reversed pulmonary fibrosis. In a rat myocardial infarction model, ICG-001 was administrated subcutaneously at the dose of 50 mg kg day for 10 days which significantly improved cardiac contractile function after myocardial infarction in the rats.

Bisindolylmaleimide VII is a selective inhibitor of protein kinase C.