dp-c-4

DP-C-4 is a Cereblon-based dual PROTAC for simultaneous degradation of EGFR and PARP[1]. DP-C-4 (1-50 μM; 24 hours) has degradation effects on EGFR and PARP simultaneously in a dose-dependent manner in SW1990 cells[1]. [1]. Mengzhu Zheng, et al. Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP. J Med Chem. 2021 May 26.

(Rac)-PROTAC PARP/EGFR ligand 1 包含用来结合PARP和EGFR的配体，以及用于募集E3连接酶（诸如VHL、CRBN、MDM2和IAP）的PROTAC linker。(Rac)-PROTAC PARP/EGFR ligand 1 可用于合成PROTAC DP-C-4，DP-C-4 是一种基于CRBN的双PROTAC，可同时降解EGFR和PARP。

N-Descyclopropanecarbaldehyde Olaparib, an Olaparib analogue, incorporates a DOTA moiety. It acts as a CRBN-based ligand for the formation of novel dual EGFR and PARP PROTAC, DP-C-4[1]. N-Descyclopropanecarbaldehyde Olaparib is suitable for radiolabeling with F-18 or a fluorophore to visualize tumors using positron emission tomography (PET) or optical imaging[2].