Amantadine is used both as an antiviral and an anti-parkinsonian drug. Amantadine is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopaminereuptake. The drug has many effects in the brain, including the rel
GBR-12935 is a piperazine derivative. It is an effective and selective dopaminereuptake inhibitor. GBR-12935 is now widely used in animal research into Parkinson's disease and the dopamine pathways in the brain.