Vanoxerine

Name: Vanoxerine
Brand: TargetMol
SKU: T23501
Rating: 4.5 (1 reviews)

还可以

产品编号 T23501Cas号 67469-69-6

Vanoxerine is an antagonist of dopamine transporter (Ki: 16.9nM).

还可以

产品编号 T23501Cas号 67469-69-6

Vanoxerine is an antagonist of dopamine transporter (Ki: 16.9nM).

规格	价格	库存	数量
25 mg	¥ 10,600	待询

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产品介绍

生物活性

产品描述	Vanoxerine is an antagonist of dopamine transporter (Ki: 16.9nM).
靶点活性	Dopamine reuptake:1 nM (Ki)
体外活性	As an antagonist of DAT, vanoxerine is developed for treatment of Parkinson's disease and depression but has no effect on these diseases. Vanoxerine is also found to have desirable cardiac antiarrhythmic properties. It is a blocker of cardiac hERG (IC50:0.84nM). It also blocks the ICa,L and hNav1.5 channel (IC50: 320nM and 830nM, respectively). Vanoxerine does not significantly prolong Purkinje fiber APD60 and APD90 and has no significant effect on QT or TDR.

化学信息

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度信息	DMSO: Soluble