donepezil

Donepezil (Aricept) 是一种AChE 抑制剂，对牛 AChE 和人 AChE 的IC50分别为 8.12 nM 和 11.6 nM。

(-)-Donepezil is an isomer of Donepezil -- a nootropic acting as an inhibitor of acetylcholinesterase.

(+)-Donepezil is an isomer of Donepezil -- a nootropic acting as an inhibitor of acetylcholinesterase.

Donepezil HCl(Aricept) 是可逆的选择性AChE 抑制剂，IC50=6.7 nM，对 AChE 的选择性高于 BuChE。Donepezil Hydrochloride (Aricept) 对 Aβ42 神经毒性具有神经保护作用。

Donepezil-d7 Hydrochloride 是 Donepezil Hydrochloride 的氘代化合物。

6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil . It is formed through dealkylation by the cytochrome P450 (CYP) isoform CYP2D6. It inhibits human ether a go-go (hERG) channels (IC50 = 1.5 μM in HEK293 cells expressing hERG).

Donepezil N-oxide is an active metabolite of the acetylcholinesterase inhibitor donepezil . Donepezil N-oxide inhibits cholinesterase (ChE) activity in human erythrocytes in a concentration-dependent manner, exhibiting 45.5% inhibition when used at a concentration of 20 μM.

Dihydro Donepezil, also known as Dihydro E2020, is a metabolite derived from Donepezil. Donepezil is a highly specific and potent inhibitor of acetylcholinesterase (AChE) with IC50 values of 8.12 nM and 11.6 nM for butyrylcholinesterase (bAChE) and human acetylcholinesterase (hAChE), respectively [1].

Dehydrodeoxy donepezil is an inhibitor of acetylcholinesterase (AChE)

Desbenzyl Donepezil Hydrochloride 是 Donepezil 的杂质。

Donepezil-d5 是 Donepezil 的氘代化合物。Donepezil 的 CAS 号为 120014-06-4。Donepezil 是一种AChE抑制剂，对牛 AChE 和人 AChE 的IC50分别为 8.12 nM 和 11.6 nM。

(±)-Donepezil-d4 HCl 是 (±)-Donepezil HCl 的氘代化合物。(±)-Donepezil HCl 的 CAS 号为 110119-84-1。

Deoxy donepezil is a potential impurity found in bulk preparations of the acetylcholinesterase inhibitor donepezil .1It is produced as a by-product during donepezil synthesis.2 1.Krishna Reddy, K.V.S.R., Moses Babu, J., Anil Kumar, P., et al.Identification and characterization of potential impurities of donepezilJ. Pharm. Biomed. Anal.35(5)1047-1058(2004) 2.Krizmanic, I., Lerman, L., Samardzic, Z., et al.Impurities of donepezil(2009)

PQM130是一种魏罗酮-多奈哌齐杂化化合物，能透过大脑。PQM130是多靶点的候选药物，可用于Aβ1-42低聚物引起的神经毒性，还具有抗炎活性。它是具有神经保护作用的、有潜力的抗 AD 药物。

AChE-IN-67(Compound 8n),一种AChE抑制剂,具有0.033 μM的IC50,活性类似于Donepezil.其高血脑屏障(BBB)通透性使其在阿尔茨海默病研究中具有潜在应用价值.