dofetilide

Dofetilide (UK 68789) 是一种具有口服活性、有效的且特异性的IKr 阻滞剂，作为 III 类抗心律失常药物。Dofetilide 可用于心血管疾病研究。

Dofetilide N-oxide (UK-116856), a metabolite of dofetilide, is associated with the parent compound's ability to block potassium channels, categorizing it as a tertiary antiarrhythmic drug.

Dofetilide-D4 (UK 68789 D4)，a deuterium-labeled version of Dofetilide，is categorized as a Class III antiarrhythmic medication.

RPR-260243 is a novel activator of HERG and modifies HERG currents inhibited by dofetilide (IC50 = 58 nM).

VU0405601是KV11.1通道的高效药理激活剂，通过hERG激动作用保护心肌组织免受多非利特（Dofetilide）等hERG抑制剂诱发的心律失常与室性心动过速。