dimethyldioctadecylammonium (bromide)

Dimethyldioctadecylammonium (DDA) is a cationic amphipathic lipid. DDA liposomes containing an Ag85B-ESAT-6 antigen induce antigen deposition at an intramuscular or subcutaneous injection site in mice, increasing immune cell exposure to the antigen. In a guinea pig model of M. tuberculosis infection, spleen bacterial load is reduced and lung and spleen lesion numbers are decreased when the mycobacterial lipid antigens Ac2SGL and PIM2 are administered in liposomes comprised of DDA and a synthetic analog of the mycobacterial cord factor trehalose 6,6-dibehenate (TDB). DDA has also been used in the study of lipid bilayer dynamics.

Dimethyldioctadecylammonium-d3bromide (Dioctadecyldimethylammonium-d3bromide) 是一种氘代标记的合成阳离子脂质，源于Dimethyldioctadecylammonium bromide。该化合物通常用于基因转染和疫苗开发，因为其通过正电铵头基团和两条长疏水尾巴构成的独特结构，适合于形成脂质体和其他基于脂质的纳米颗粒，从而高效递送遗传物质进入细胞。此外，DDAB 在生物技术领域应用广泛，包括作为表面活性剂、乳化剂和织物柔软剂使用。然而，其潜在的毒性和刺激性要求在处理时需格外谨慎。