deltarasin

Deltarasin 是一种 KRAS-PDEδ 相互作用的小分子抑制剂，与纯化的 PDEδ 结合，Kd 值为 38 nM。

Deltarasin is a high affinity PDEδ-KRAS interaction inhibitor. Deltarasin can inhibit KRAS-PDEδ interactions by binding to a hydrophobic pocket on PDEδ, resulting in the impairment of cell growth, KRAS activity, and RAS RAF signaling in human pancreatic ductal adenocarcinoma cell lines. The anti-cancer cell activity of deltarasin can be enhanced by simultaneously blocking tumor protective autophagy

HA-23 is a Ca(2+)-channel blocker.