dbco amine

DBCO-amine 是一种可切割的 ADC 接头，用于合成抗体-药物偶联物。

Sulfo DBCO-amine is an alkyl chain-derived PROTAC linker utilized for synthesizing PROTACs[1].

DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE and antibody (e.g., DBCO-VCpAB MMAE and DBCO-TRX MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively) [1].

DBCO-PEG4-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG4-amine can be used in the synthesis of FPM-PEG4-DBCO (a homobifunctional azide-to-azide cross-linker)[1].

Sulfo DBCO-PEG4-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-C2-PEG4-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-C3-PEG4-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-NHCO-PEG12-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-NHCO-PEG2-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-NHCO-PEG6-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-PEG1-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-PEG2-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-PEG6-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-PEG9-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-SS-amine is a cleavable linker vital in ADC synthesis. DBCO-SS-amine joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

DBCO-PEG6-amine TFA 是一种PEG类的PROTAC linker，用于合成PROTAC分子。作为一种点击化学试剂，DBCO-PEG6-amine (TFA) 具有DBCO基团，能够与含有Azide基团的分子进行应力（strain）促进的炔-叠氮环加成反应（SPAAC）。

DBCO-PEG3-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-PEG8-amine 是一种由 DBCO、PEG 单元和氨基 (Amine) 构成的 PEG 衍生物。Maleimide 能与巯基 (-SH) 结合，形成稳定的硫醚键。氨基可与其他化学基团 (如羧基、醛基) 发生反应，生成稳定的化学键。

DBCO-PEG23-amine 是一种由 DBCO、PEG 单元和氨基 (Amine) 组成的 PEG 衍生物。Maleimide 可以与巯基 (-SH) 反应生成稳定的硫醚键。氨基能够与其他化学基团（如羧基、醛基等）反应形成稳定的化学键。

DBCO-PEG-Amine (MW 3400) (DBCO-PEG-NH2 (MW 3400)) 是一种由 DBCO、PEG 单元和氨基（Amine）构成的 PEG 衍生物。氨基能够与羧基、醛基等化学基团反应形成稳定化学键。DBCO-PEG-Amine (MW 3400) 具有 DBCO 基团，可与含 Azide 基团的分子发生应力促进的炔-叠氮环加成反应（SPAAC）。

DBCO-PEG-Amine (MW 5000) (DBCO-PEG-NH2 (MW 5000)) 是一种包含 DBCO、PEG 链段和氨基 (Amine) 的 PEG 衍生物。其中的氨基能够与羧基、醛基等化学基团反应，生成稳定化学键。DBCO 基团则可与具有 Azide 基团的分子进行环张力 (strain) 促进的炔-叠氮环加成反应 (SPAAC)。

Azido-PEG10-amine是一种不可降解(non-cleavable)的ADC linker和PEG类的PROTAC linker，可用于合成抗体偶联分子(ADC)和PROTAC，可以和含有Alkyne、DBCO或BCN基团的分子发生点击化学反应。

Azido-PEG11-amine是一种PEG类的PROTAC linker，可用于合成PROTAC分子，其Azido基团可以和含有Alkyne、DBCO或BCN基团的分子发生点击化学反应。

Azido-PEG7-amine是一种不可降解(non-cleavable)的ADC linker和PEG类的PROTAC linker，可用于合成抗体偶联分子(ADC)和PROTAC，可以和含有Alkyne、DBCO或BCN基团的分子发生点击化学反应。