cortistatin-a

BRD6989 是天然产物皮质抑素 A 的类似物，可抑制CDK8并上调IL-10，抑制重组 CDK8 或 CDK19 复合物的激酶活性。它选择性结合 CDK8 复合物，IC50约为 200 nM。

Cortistatin A is a potent and selective mediator-associated kinase CDK8 and its paralogue CDK19 inhibitor.

Cortistatin-8 acetate 是一种皮质抑素类似物，是一种GHS-R拮抗剂，对生长激素促分泌素受体有抑制作用。Cortistatin-8 acetate 是一种合成皮质抑素衍生的生长素释放肽受体配体，不会改变人类对酰化生长素释放肽或海沙瑞林的内分泌反应。

Cortistatin 14, human, rat acetate 是一种与 somatostatin-14 结构相似的神经肽，具有抗惊厥、神经保护作用和显着的抗炎特性。 Cortistatin 14, human, rat acetate 通过与生长抑素受体结合并发挥其功能。

Cortistatin 29 (1-13) 是多肽分子，其序列是 Glp-ERPPLQQPPHRD。

Cortistatin-14 is a neuropeptide have structural similarity to somatostatin-14. It is produced in the cortex and hippocampus of central nervous system.

Cortistatin 14 is a somatastatin-like neuropeptide with neuronal depressant and sleep modulating properties. Cortistatin 14 is present primarily in the cortex and hippocampus.

Cortistatin 29，一种具备高亲和力结合至所有生长抑素(SS)受体亚型的神经肽，其对SSTR1、SSTR2、SSTR3、SSTR4、SSTR5的IC50值分别为2.8, 7.1, 0.2, 3.0, 13.7 nM。该化合物不仅能减轻神经性疼痛，还表现出抗纤维化作用。

Cortistatin-29 is a neuropeptide that is structurally similar to somatostatin-28. It is produced by cleavage of preprocortistatin to procortistatin, which is cleaved at dibasic amino acids to form cortistatin-29 and cortistatin-14 as well as other partial cleavage products. Cortistatin mRNA is expressed in the human brain and in interneurons of the rat hippocampus and cerebral cortex. Cortistatin-29 binds to somatostatin (SST) receptors with IC50 values of 2.8, 7.1, 0.2, 3, and 13.7 nM for SST1-5, respectively. Cortistatin-29 is found at similar levels as cortistatin-14 in mouse AtT20 cells but is secreted at a lower level. Cortistatin-29 corresponds to residues 85-112 of the rat peptide sequence.

Cortistatin-14 acetate 是一种与生长抑素-14结构相似的神经肽，通过生长抑素受体 (sst1-sst5) 结合并发挥作用。Cortistatin-14 acetate 具有抗惊厥、神经保护作用和显著的抗炎作用。

Cortistatin-14 是一种与生长抑素-14结构相似的神经肽，具有抗惊厥和神经保护作用，通过激活 sst（2）、生长素释放肽和 GABA（A B） 受体损害小鼠的识别记忆巩固，可用于研究脓毒症引发的认知障碍。

Cortistatin-29 (1-13) is a neuropeptide and cleavage product of cortistatin-29 , which is a cleavage product of procortistatin. Cortistatin-29 (1-13) corresponds to the first 13 amino acids of cortistatin-29.