cl8490

Methazolamide (CL 8490) 是一种磺胺衍生物，用作碳酸酐酶 (carbonic anhydrase) 抑制剂，对人 carbonic anhydrase II 的 Ki=为 14 nM。它是降低眼压的药物，能够抑制由青光眼及其他眼病引起的眼压升高的作用。

Methazolamide-D6 is intended for use as an internal standard for the quantification of methazolamide by GC- or LC-MS. Methazolamide (T0106) is a carbonic anhydrase inhibitor. It reduces intraocular pressure and cerebrospinal fluid flow in a rat model of glaucoma. Methazolamide (T0106)reduces electroshock-induced seizures in rats with an ED50 value of 19.2 mg/kg. It also inhibits production of reactive oxygen species (ROS)in a primary cortical neuron (PCN)cellular model of subarachnoid hemorrhage (SAH)and reduces cerebral edema in a mouse model of SAH.3 Methazolamide (T0106) is larvicidal,with a 50% larvicidal concentration (LC50)value of 724 ppm,but has no activity when administered in the diet to adult A. aegypti. Formulations containing methazolamide have been used in the treatment of glaucoma.