ch 5164840.

Azumolene sodium anhydrous is a muscle relaxant that inhibits the release of calcium from skeletal muscle sarcoplasmic reticulum. Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptor. Azumolene, an equipotent dantrolene analog, inhibits a component of SOCE coupled to activation of RyR1 by caffeine and ryanodine, whereas the SOCE component induced by thapsigargin is not affected.

CH5164840是一种强效、口服活性的变构 HSP90 抑制剂 (IC50 = 4.1 nM)。它通过降解多种肿瘤相关的底物蛋白 (如 HER2, Akt) 抑制肿瘤生长，用于各种实体瘤研究。