cefsulodin

Cefsulodin is a β-lactam antibiotic that lyses actively-growingE. coliby binding specifically to the intermembrane proteins, penicillin-binding proteins 1a and b, whose transglycosylase and transpeptidase activities are involved in cell elongation and septation.1Cefsulodin has been used in combination with other β-lactam antibiotics, such as cefazolin as a strategy to circumvent drug resistance.2

Cefsulodin (SCE-129) 对铜绿假单胞菌和对青霉素及庆大霉素敏感的菌株具有类似于庆大霉素和地贝汉的高效活性。然而，对于耐青霉素的铜绿假单胞菌菌株，尤其是那些也耐庆大霉素者，其效力有所减弱。对于马尔托菲拉铜绿假单胞菌，SCE-129 显示出与青霉素、庆大霉素和地贝汉相似的最小抑制浓度。Pseudomonas cepacia 菌株通常对 SCE-129 和青霉素表现出中度耐药性，而对庆大霉素和地贝汉表现出高度耐药性。

Cefsulodin sodium (Sulcephalosporin) 是β内酰胺抗生素，对缘脓杆菌和肠杆菌有活性。