cdk ligand for protac

CDK ligand for PROTAC is a CDK inhibitor with antitumor activity. It has been used to design PROTAC CDK4/6 degraders.

CDK ligand for PROTAC hydrochloride is a CDK inhibitor with antitumor activity. It has been used to design PROTAC CDK4/6 degraders.

PROTAC CDK9 ligand-1 is a CDK9 ligand that can be used in the synthesis of PROTACs.

TMX-2039 是一种泛CDK (pan-CDK) 抑制剂，能够抑制细胞周期CDK（CDK1、CDK2、CDK4、CDK5和CDK6）以及转录CDK（CDK7和CDK9），其IC50值分别为2.6、1.0、52.1、0.5、35.0、32.5和25 nM。TMX-2039 可作为PROTAC的靶蛋白配体 (Ligands for Target Protein)。

FLT3/CDKs ligand-1 (Compound 14) 作为一种靶向化合物，要针对细胞周期蛋白依赖性激酶 (CDK) 和 FMS 样酪氨酸激酶 3 (FLT3)，通过促进这些蛋白的降解，有效抑制FLT3/CDK相关白血病细胞的增殖与存活。此外，该配体还可以被用来制备PROTAC FLT3/CDKs Degrader-1。