cbx7 chromodomain

MS37452 是 CBX7 chromodomain 与 H3K27me3 结合的竞争性抑制剂，Ki 为 43 µM。它通过置换 CBX7 与前列腺癌细胞中INK4A ARF 基因座的结合，抑制多梳抑制复合物靶基因 p16 CDKN2A 的转录。

UNC4976 is a peptidomimetic positive allosteric modulator (PAM) of the CBX7 chromodomain, facilitating its binding to nucleic acids.

MS351 is an antagonist of chromobox 7 (CBX7) that acts by binding the CBX7 chromodomain. It enhances the binding of long noncoding RNA to the CBX7 chromodomain when used at 25 μM. MS351 induces transcriptional derepression of CBX7 target genes, including p16 (INK4a), in mouse embryonic stem cells and human prostate cancer PC3 cells.

UNC3866 CBX7-H3 相互作用的有效拮抗剂，IC50为 66±1.2 nM。

UNC4976 TFA为CBX7染色质结构域与核酸结合的PAM（正变构调节剂）拟肽。通过拮抗H3K27me3，特异性阻断CBX7对靶基因的募集，同时促进了与DNA和RNA的非特异性结合。