c188

C188 is a cell-permeable naphthol compound and a STAT3 inhibitor. C188 inhibits IL-6-stimulated STAT3 Tyr705 phosphorylation and nuclear translocation in HepG2 cells by targeting STAT3 SH2 domain peptide-binding pocket, while exhibiting little effect agai

C188-9 (TTI-101) 是一种Stat3抑制剂，其Kd 值为 4.7 nM。它诱导 AML 细胞系和原代标本凋亡，抑制原代 AML 细胞集落形成。它抑制 G-CSF 诱导的 STAT3 激活和 STAT3 依赖性基因表达。

LOC1886 是 GPX4 的共价抑制剂，其效力略逊于 RSL3 和 ML162。