biphasic

L-Albizziin (2-Methoxyidazoxan monohydrochloride) 是高效的 alpha 2r 肾上腺素受体选择性拮抗剂，对 imidazoline 拮抗作用很小或没有。它对 (豚鼠) alpha 2D 肾上腺素受体 (pKd9.7) 的亲和力明显高于 (兔子) alpha 2A 肾上腺素受体 (pKd8.2)。

Melitracen hydrochloride (Thymeol hydrochloride) 是一种可口服的双相抗抑郁药和抗焦虑药。它可以通过突触前膜抑制去甲肾上腺素和5-羟色胺(5-HT)的吸收，从而诱导突触空间中单胺递质的增加。

RH1 (NSC 697726) 是一种生物还原性抗癌化合物，在体外表现出剂量依赖性双相效应，在较高剂量下诱导细胞凋亡，在较低剂量下诱导衰老。

Rosmanol 能够显著抑制脂多糖诱导的 INOS、COX-2 的表达，抑制低密度脂蛋白的氧化，并具有抗炎作用。

RDS-127在大鼠自发运动活动中引起双相剂量相关变化，与APO的报告效果相似。与APO相比，RDS-127的运动刺激效果更为强烈，其效力增强3倍，持续时间延长4倍。在选择性上，RDS-127明显优于APO，它更倾向于激活黑质纹状体途径中的DA自身受体，而不是突触后DA受体。

Cardionogen-2 是一种双相的心脏生成调节剂，根据干预的阶段不同，能够促进或阻碍心脏的形成。它在小鼠胚胎干细胞和斑马鱼胚胎中抑制 Wnt β-catenin 依赖性转录。

TT-232 TFA（147159-51-1 free base）诱导人结肠肿瘤细胞系 SW620 中磷酸酪氨酸磷酸酶活性的双相激活。

Ru360, an oxygen-bridged dinuclear ruthenium amine complex, is a selective mitochondrial calcium uptake inhibitor. Ru360 potently inhibits Ca2+ uptake into mitochondria with an IC50 of 0.184 nM. Ru360 binds to mitochondria with high affinity (Kd of 0.34 nM). Ru360 has antiarrhythmic and cardioprotective effects[1][2]. Ru360 permeates slowly into the cell, and specifically inhibits mitochondrial calcium uptake in intact cardiomyocytes and in isolated heart. 1 μm Ru360 is taken up by myocardial cells and accumulated in the cytosol in a biphasic manner[1]. During pelleting hypoxia, Ru360 (10 µM) significantly improves cell viability in wild type cardiomyocytes[3]. Ru360 (15-50 nmol/kg) treatment abolishes the incidence of arrhythmias and haemodynamic dysfunction elicited by reperfusion in a whole rat model. Ru360 administration partially inhibits calcium uptake, preventing mitochondria from depolarization by the opening of the mitochondrial permeability transition pore (mPTP)[1]. [1]. G de J García-Rivas, et al. Ru360, a Specific Mitochondrial Calcium Uptake Inhibitor, Improves Cardiac Post-Ischaemic Functional Recovery in Rats in Vivo. Br J Pharmacol. 2006 Dec;149(7):829-37. [2]. M A Matlib, et al. Oxygen-bridged Dinuclear Ruthenium Amine Complex Specifically Inhibits Ca2+ Uptake Into Mitochondria in Vitro and in Situ in Single Cardiac Myocytes. J Biol Chem. 1998 Apr 24;273(17):10223-31. [3]. Lukas J Motloch, et al. UCP2 Modulates Cardioprotective Effects of Ru360 in Isolated Cardiomyocytes During Ischemia. Pharmaceuticals (Basel). 2015 Aug 4;8(3):474-82.

SOS1 agonist-1 (compound 79) 作为一种SOS1激动剂，具备针对鸟嘌呤核苷酸交换因子(SOS1)的高效活性。SOS1负责催化RAS上GDP向GTP的交换，进而调控RAS的激活状态。该激动剂通过增加RAS的核苷酸交换率，提升细胞内RAS-GTP的水平，触发ERK1/2磷酸化过程中的双向信号变化，从而展现其抗癌功效。

Epinodosin induces significant DNA damage to HepG2 cells in a time- and dose-dependent manner.Epinodosin has a biphasic, dose-dependent effect on root growth and a strong inhibitory effect on root hair development in Lactuca sativa L. seedlings.